Cerebellar Neuromodulation to Enhance Fear Extinction and Predict Response to Exposure Therapy

Completed · Not applicable · Has a placebo group

Conditions studied: Anxiety Disorders, Social Phobia

In brief

Emerging neuroimaging studies have shown that the cerebellum contributes to different aspects of timing, prediction, learning, and extinction of conditioned responses to aversive stimuli, factors that may be relevant to the success of exposure based behavioral therapy. Our goals are to determine the cerebellar contributions to fear extinction by attempting to modulate key pathways in this process by theta burst stimulation. The long term goal is to lay the foundation for future studies in which neuromodulation is used to augment exposure therapy.

Key facts

Study ID

NCT03275337

Run by

Laureate Institute for Brain Research, Inc.

People needed

60

Starts

2017-08-01

Expected to finish

2019-12-31

Last updated by the study team

2020-09-01

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Generalize Anxiety or Social Phobia with an OASIS score =>8

You may not qualify if…

• Safety concerns related to undergoing an fMRI scan or tDCS, such as metal in the head, history of unprovoked seizures in self or a first-degree family member, medications that reduce seizure threshold, pregnant or planning to become pregnant.
• History of Post Traumatic Stress Disorder, Obsessive Compulsive Disorder, Panic Disorder, Current Major Depressive Illness, Substance Abuse in the past 1-year, or any thought disorder such as schizophrenia or bipolar disorder.

Where it is running

• Laureate Institute for Brain Research — Tulsa, Oklahoma, United States

Full record on ClinicalTrials.gov

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