A Study of Cobimetinib Plus Atezolizumab Versus Pembrolizumab in Participants With Previously Untreated Advanced BRAFv600 Wild-Type Melanoma

Stopped early · Phase 3

Conditions studied: Advanced BRAFV600 Wild-type Melanoma

In brief

This is a Phase III, multicenter, open-label, randomized study designed to evaluate the efficacy, safety, and pharmacokinetics of cobimetinib plus atezolizumab compared with pembrolizumab in treatment-naive participants with advanced BRAFV600 wild-type melanoma.

Key facts

Study ID

NCT03273153

Run by

Hoffmann-La Roche

People needed

446

Starts

2017-12-11

Expected to finish

2021-02-19

Last updated by the study team

2022-09-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Disease-Specific Inclusion Criteria
• Histologically confirmed locally advanced and unresectable or metastatic melanoma
• Naive to prior systemic anti-cancer therapy for melanoma
• Documentation of BRAFV600 wild-type status in melanoma tumor tissue through use of a clinical mutation test approved by the local health authority
• A representative, formalin-fixed, paraffin-embedded (FFPE) tumor specimen in a paraffin block (preferred) or 20 slides containing unstained, freshly cut, serial sections must be submitted along with an associated pathology report prior to study entry. If 20 slides are not available or the tissue block is not of sufficient size, the patient may still be eligible for the study, after discussion with and approval by the Medical Monitor
• Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
• Age >=18 years at time of signing Informed Consent Form
• Ability to comply with the study protocol, in the investigator's judgment
• Histologically or cytologically confirmed BRAFV600 wild-type melanoma
• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
• Life expectancy >=3 months
• Adequate hematologic and end-organ function
• For women of childbearing potential: agreement to remain abstinent or use at least two forms of effective contraceptive with a failure rate of < 1% per year during the treatment period and for at least 3 months after the last dose of cobimetinib and at least 5 months after the last dose of atezolizumab or pembrolizumab
• For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures (e.g. condom), and agreement to refrain from donating sperm, for at least 3 months after the last dose of cobimetinib
• Willingness and ability of patients to report selected study outcomes (e.g., GHS and HRQoL) using an electronic device or paper backup questionnaires.

You may not qualify if…

• General Exclusion Criteria
• Inability to swallow medications
• Malabsorption condition that would alter the absorption of orally administered medications
• Pregnancy, breastfeeding, or intention of becoming pregnant during the study
• History of severe hypersensitivity reactions to components of the cobimetinib, atezolizumab, or pembrolizumab formulations
• Current or recent treatment with therapeutic antibiotics, live attenuated vaccines or systemic immunostimulatory/immunosuppresive medication
• Any serious medical condition or abnormality in clinical laboratory tests that, in the investigator's judgment, precludes the patient's safe participation in and completion of the study Cancer-Related Exclusion Criteria
• Ocular melanoma
• Major surgery or radiotherapy within 21 days prior to Day 1 of Cycle 1 or anticipation of needing such procedure while receiving study treatment
• Uncontrolled tumor-related pain
• Uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage more than once every 28 days
• Active or untreated central nervous system (CNS) metastases Exclusions Related to Cardiovascular Disease
• Unstable angina, new-onset angina within last 3 months, myocardial infarction within the last 6 months prior to Day 1 of Cycle 1, or current congestive heart failure classified as New York Heart Association Class II or higher
• Left ventricular ejection fraction (LVEF) below institutional lower limit of normal or <50%, whichever is lower
• Poorly controlled hypertension, defined as sustained, uncontrolled, non-episodic baseline hypertension consistently above 159/99 mmHg despite optimal medical management
• History or presence of an abnormal electrocardiogram (ECG) that is clinically significant in the investigator's opinion, including complete left bundle branch block, second- or third degree heart block, or evidence of prior myocardial infarction Exclusions Related to Infections
• HIV infection
• Active tuberculosis infection
• Severe infections within 4 weeks prior to Day 1 of Cycle 1, including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia
• Signs or symptoms of clinically relevant infection within 2 weeks prior to Day 1 of Cycle 1
• Treatment with oral or IV antibiotics within 2 weeks prior to Day 1 of Cycle 1
• Active or chronic viral hepatitis B or C infection Exclusions Related to Ocular Disease
• Known risk factors for ocular toxicity Exclusions Related to Autoimmune Conditions and Immunomodulatory Drugs
• Active or history of autoimmune disease or immune deficiency
• Prior allogeneic stem cell or solid organ transplantation

Where it is running

• Cliniques Universitaires St-Luc — Brussels, Belgium
• AZ Groeninge — Kortrijk, Belgium
• UZ Leuven Gasthuisberg — Leuven, Belgium
• Instituto Nacional de Cancer - INCa; Oncologia — Rio de Janeiro, Rio de Janeiro, Brazil
• Hospital das Clinicas - UFRGS — Porto Alegre, Rio Grande do Sul, Brazil
• Hopital Avicenne; Dermatologie — Bobigny, France
• Hopital Saint Andre CHU De Bordeaux; Dermatologie — Bordeaux, France
• Chu Site Du Bocage;Dermatologie — Dijon, France
• CHU de Grenoble - Hôpital Nord — Grenoble, France
• Centre Hospitalier Le Mans; Dermatologie — Le Mans, France
• Hopital Claude Huriez; Sce Dermatologie — Lille, France
• Hopital Timone Adultes; Dermatologie — Marseille, France
• CHU de Nantes; Cancéro-dermatologie — Nantes, France
• Hopital l Archet 2; Ginestriere, Service de; Dermatologie — Nice, France
• Groupe Hospitalier Bichat Claude Bernard — Paris, France
• Hopital Saint Louis; Dermatologie 1 — Paris, France
• Hopital Robert Debre; DERMATOLOGIE — Reims, France
• Centre Eugene Marquis; Service d'oncologie — Rennes, France
• Hopital Charles Nicolle; Dermatologie Serv. — Rouen, France
• Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O) — Toulouse, France
• Institut Gustave Roussy; Dermatologie — Villejuif, France
• Universitätsklinikum "Carl Gustav Carus"; Klinik und Poliklinik für Dermatologie — Dresden, Germany
• HELIOS Klinikum Erfurt; Klinik für Dermatologie & Allergologie — Erfurt, Germany
• Universitatsklinikum Essen; Klinik für Dermatologie — Essen, Germany
• Fiona Stanley Hospital — Murdoch, Western Australia, Australia

Full record on ClinicalTrials.gov

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