Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training
Completed · Phase 4 · Has a placebo group
Conditions studied: Age-related Cognitive Decline
In brief
The purpose of this research study is to examine the potential benefits of vortioxetine in combination with at-home computerized cognitive training program to improve cognition, such as memory, attention, and concentration. This study will compare the effectiveness of vortioxetine plus cognitive training versus placebo plus cognitive training.
Key facts
- Study ID
- NCT03272711
- Run by
- Washington University School of Medicine
- People needed
- 129
- Starts
- 2016-08-31
- Expected to finish
- 2019-01-24
- Last updated by the study team
- 2020-01-14
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Community-living men and women age 65 and older
- Age-related cognitive decline as defined by (a) self-reported cognitive dysfunction that is attributed to the aging process (in response to screening questions to the participant); (b) ability to complete cognitive battery, but still scoring less than 1 standard deviation above age-matched norms at both baseline and after the two-week cognitive training lead-in.
You may not qualify if…
- Known dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease, cerebrovascular disease) per self-report, informant report, medical records, or neuropsychological testing
- Any current psychiatric disorder
- Medical conditions that suggest shortened lifespan, such as metastatic cancer; or would prohibit safe participation in the interventions, including cardiovascular disease or musculoskeletal conditions; or with the assessments.
- Sensory impairment that would prevent participation
- IQ < 70 as estimated by the Wechsler Test of Adult Reading
- Alcohol or substance abuse within 6 months
- Concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity
- Psychotropic medications or those with likely CNS effects (none within 4 weeks prior to study entry)
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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