Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults

Completed

Conditions studied: Pre-natal Cocaine Exposure, Risk-Taking

In brief

Reward processing will be examined in prenatally exposed emerging adults in a longitudinal design. Participants will be followed for one year to see if neural markers of reward processing prospectively predict risk-taking behavior.

Key facts

Study ID

NCT03268759

Run by

Yale University

People needed

78

Starts

2017-09-15

Expected to finish

2020-09-14

Last updated by the study team

2021-05-04

Who can join

Age: 18 and older, up to 20. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ability to provide written informed consent and to comply with all study procedures.
• Healthy emerging adults between 18-20 years of age (the age of the currently followed sample at the time of the proposed start date).

You may not qualify if…

• 1. A serious neurological or endocrine disorder or any medical condition or treatment known to affect the brain. 2. A medical condition that requires treatment with a medication with psychotropic effects.
• Evidence of stroke or space occupying lesions observed on conventional, clinical MR images.
• Any contraindications to MRI scanning (i.e., metal implants, pacemakers, etc.) 5. History of loss of consciousness (LOC) for longer than 30 minutes or LOC with any neurological sequelae.
• DSM-5 criteria for intellectual disability. 7. Current or a history of active neurological or psychiatric disorders, such as psychosis, bipolar illness, major depression, organic brain disease, dementia or DSM-V Axis I Psychiatric Disorder, including current alcohol or substance disorders. Participants will not be excluded for substance or alcohol use, only the presence of substance disorders.
• Current pregnancy. Female participants will be excluded if they report being currently pregnant or present positive for pregnancy after being given a urine test at the time of recruitment or scanning. If they become pregnant during the one-year follow-up duration of the study after the MRI scan is completed, they will remain in the study for the quarterly follow-ups and be referred to pre-natal care if they have not begun such care already.

Where it is running

• Child Study Center — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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