Heart Failure and Aortic Stenosis Transcriptome

Recruiting now

Conditions studied: Heart Failure, Aortic Stenosis

In brief

This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.

Key facts

Study ID

NCT03268135

Run by

IRCCS Policlinico S. Donato

People needed

500

Starts

2016-05-30

Expected to finish

2027-12-31

Last updated by the study team

2025-04-30

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Non end-stage heart failure
• left ventricle restoration surgery (SVR)
• End Systolic Volume Index (ESVI) >35 ml/m2
• Ejection Fraction (EF)<40%
• previous transmural anterior myocardial infarction (MI)
• age: 40-75
• End-stage heart failure
• left ventricle assisted device (LVAD) surgery
• age: 40-75
• Ejection Fraction (EF) <25%
• End Systolic Volume Index (ESVI)≥60 ml/m2
• Aortic Stenosis
• aortic valve replacement
• intracardial pressure difference >40 mmHg
• septal diameter ≥1.3 cm

You may not qualify if…

• Non end-stage heart failure
• End Systolic Volume Index (ESVI)<35 ml/m2
• Ejection Fraction (EF)>40%
• Time from MI unknown
• Pregnancy
• Other genetic diseases
• Neoplasms
• Collagenopathies
• Chemo/radiotherapy
• Prolonged use of corticosteroids
• Infections
• Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive
• End-stage heart failure
• EF>25%
• Time from MI unknown
• Pregnancy
• Other genetic diseases
• Neoplasms
• Collagenopathies
• Chemo/radiotherapy
• Prolonged use of corticosteroids
• Infections
• Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive
• Aortic Stenosis
• coronaropathies

Where it is running

• Irccs Policlinico San Donato — San Donato Milanese, Milan, Italy (enrolling)
• Ospedale San Raffaele — Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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