Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function
Completed · Not applicable · Has a placebo group
Conditions studied: Hypertension, Prehypertension, Aging
In brief
The purpose of this study is to assess the efficacy of inspiratory muscle strength training for lowering blood pressure and improving physiological function (vascular, motor, and cognitive) in middle-aged and older adults with elevated systolic blood pressure.
Key facts
- Study ID
- NCT03266510
- Run by
- Douglas Seals
- People needed
- 64
- Starts
- 2017-11-25
- Expected to finish
- 2020-10-30
- Last updated by the study team
- 2021-05-07
Who can join
Age: 50 and older, up to 64. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ability to provide informed consent
- Willing to accept random assignment to condition
- Women will be confirmed as postmenopausal (either natural or surgical) based on cessation of menses for >1 year.
- Resting systolic blood pressure 120-159 mmHg
- Resting diastolic blood pressure <100 mmHg
- Subjects taking anti-hypertensive medications will be included provided they meet the other inclusion criteria, including elevated systolic blood pressure. These medications will not be withheld prior to experimental protocols.
- Free from alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual or Mental Disorders (DSM-IV)
You may not qualify if…
- Current smoking
- Chronic clinical disease (e.g., inflammatory bowel disease/irritable bowel syndrome, coronary artery/peripheral artery/cerebrovascular diseases, diabetes, chronic kidney disease requiring dialysis, neurological disorders or diseases that may affect motor/cognitive function [multiple sclerosis, Parkinson's disease, polio, Alzheimer's disease, dementia, or other brain diseases of aging]), except hypertension
- Postmenopausal <1 year
- Scoring <21 on the mini-mental state examination
- Moderate or sever peripheral artery disease (ankle-brachial index 0.7)
- Taking a medication that your doctor deems unsafe to hold for >1 week
- A graded exercise test will be performed by all subjects. If there is physician concern or an adverse event, the subject will not participate in the study.
- No weight stable in the prior 3 months (>2 kg weight change) or unwilling to remain weight stable throughout study (rationale: recent weight change or weight loss can influence vascular function)
Where it is running
- Integrative Physiology of Aging Laboratory — Boulder, Colorado, United States
Full record on ClinicalTrials.gov
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