Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis

Stopped early

Conditions studied: Inflammatory Bowel Diseases

In brief

1. To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone. 2. To demonstrate inflammatory cytokine imbalance, i.e., increased pro-inflammatory cytokines. Presence of these abnormalities would make patients with ulcerative proctitis and proctosigmoiditis good candidates for future sacral nerve stimulation therapy.

Key facts

Study ID

NCT03259659

Run by

Johns Hopkins University

People needed

20

Starts

2017-11-30

Expected to finish

2020-02-29

Last updated by the study team

2020-07-31

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• No any systemic diseases;
• no proctitis or proctosigmoiditis;
• no history of gastrointestinal surgery;
• no symptoms of diarrhea or fecal urgency during the past 2 weeks;
• not taking any medications except contraceptives during the past 2 weeks;
• age 18-65.

You may not qualify if…

• None.

Where it is running

• Johns Hopkins University — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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