A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation

Completed · Phase 4

Conditions studied: Anesthesia

In brief

Hypothesis: A combination of midazolam with dexmedetomidine for sedation during third molar surgery will provide 1) superior patient satisfaction, 2) superior operator satisfaction and 3) no significant hemodynamic or respiratory changes when compared to a sedation combination of midazolam, fentanyl and propofol for sedation during third molar surgery.

Key facts

Study ID

NCT03255824

Run by

Montefiore Medical Center

People needed

144

Starts

2018-03-20

Expected to finish

2019-12-27

Last updated by the study team

2020-05-13

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction
• ASA Class I or II
• English-speaking and Spanish-speaking subjects

You may not qualify if…

• ASA Class III or higher
• Patients taking alpha-2 agonists or benzodiazepines
• Allergy or drug reaction to any of the drugs used in this study (benzodiazepines, opioids, propofol, alpha-2 agonists, NSAIDs, local anesthetic)
• BMI greater than 30
• History of or current substance abuse or alcoholism
• History of mood-altering medications, tranquilizers, or antidepressants.
• Pregnant females

Where it is running

• Montefiore Medical Center — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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