Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer

Running, not enrolling · Not applicable

Conditions studied: Breast Cancer, Locally Advanced Breast Cancer

In brief

This study is being done to help the investigators determine how accurate the sentinel lymph node biopsy (SLNB) procedure is in identifying residual cancer cells after neoadjuvant chemotherapy in patients presenting with locally advanced breast cancer.

Key facts

Study ID

NCT03255577

Run by

Memorial Sloan Kettering Cancer Center

People needed

162

Starts

2017-08-17

Expected to finish

2027-08-30

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients over 18 years of age with biopsy-proven breast cancer
• Patients presenting with locally advanced disease in the breast (cT4) and/or in the nodes (cN2/N3) as assessed by clinical exam and imaging
• Patients presenting to surgery clinic after receipt of NAC at outside hospital with documentation of cT4 or cN2/3 disease on initial outside physical exam and imaging studies
• Patients receiving NAC and having a nodal complete clinical response as assessed by physical exam

You may not qualify if…

• Patients with a prior history of ipsilateral breast cancer
• Pregnant patients
• Patients with persistent palpable axillary nodes after NAC, as assessed by physical exam
• Patients not consenting to ALND

Where it is running

• BAPTIST ALLIANCE - MCI (Data Collection Only) — Miami, Florida, United States
• Memorial Sloan Kettering at Basking Ridge (Consent and Follow Up) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (Consent only and Follow Up) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Commack — Commack, New York, United States
• Memorial Sloan Kettering Westchester — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Memorial Sloan Kettering Nassau (Consent only and Follow Up) — Uniondale, New York, United States

Full record on ClinicalTrials.gov

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