A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF)

Completed · Phase 2 · Has a placebo group

Conditions studied: Heart Failure With Preserved Ejection Fraction

In brief

The objective of the CAPACITY-HFpEF study is to evaluate the safety and efficacy of IW-1973 compared with placebo when administered daily for approximately 12 weeks to patients with HFpEF. The study will evaluate the effect of oral IW-1973 on peak exercise capacity in patients with HFpEF, with or without permanent or persistent atrial fibrillation.

Key facts

Study ID

NCT03254485

Run by

Akebia Therapeutics

People needed

196

Starts

2017-11-07

Expected to finish

2019-08-19

Last updated by the study team

2022-09-15

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is an ambulatory male or female ≥45 years old at the Screening Visit
• Patient has heart failure with ejection fraction (EF) of ≥40%
• Patient has a peak VO2 measuring <80% of age- and sex-adjusted normal values
• Patient has evidence in medical history supporting clinical heart failure syndrome consisting of at least 1 of the following:
• Hospitalization or emergency department visit for heart failure within the past year
• Elevated B-type natriuretic peptide (BNP) or N-terminal pro b-type natriuretic peptide (NT-proBNP) within the past 6 months
• Echocardiographic evidence within the past 12 months of at least 2 of the following: left ventricular (LV) hypertrophy, left atrial (LA) enlargement, or diastolic dysfunction
• Hemodynamic evidence of elevated filling pressures
• Patient meets at least 2 of the following criteria at the Screening Visit:
• Diagnosis of type 2 diabetes mellitus or prediabetes
• History of hypertension
• Body mass index (BMI) >30 kg/m2
• Age ≥70 years

You may not qualify if…

• Patient has had acute coronary syndrome or percutaneous coronary intervention within 30 days before Randomization
• Patient has had cardiac transplantation or has cardiac transplantation planned during the study
• Patient has had cardiac artery bypass graft, cardiac mechanical support implantation, or other cardiac surgery in the 3 months before the Screening Visit or planned during the study
• Patient has severe chronic obstructive coronary disease as defined by chronic oxygen dependence
• Patient had had heart failure hospitalization with discharge within 30 days before the Screening Visit
• Patient has a history of clinically significant hypersensitivity or allergies to any of the inactive ingredients contained in the active or placebo drug products
• Patient has previously received IW-1973 in a study, or received an investigational drug during the 30 days or 5 half lives of that investigational drug (whichever is longer) before the Screening Visit, or is planning to receive another investigational drug at any time during the study
• Patient is taking specific inhibitors of phosphodiesterase 5 (PDE5), nonspecific inhibitors of PDE5, any supplements for the treatment of erectile dysfunction, riociguat, or nitrates or nitric oxide (NO) donors in any form
• Patient is taking strong cytochrome P450 3A (CYP3A) inhibitors
• Women of childbearing potential must have a negative pregnancy test prior to randomization and must agree to use protocol-specified contraception from the Screening Visit through 60 days after the final dose of study drug
• Male patients must be surgically sterile by vasectomy (conducted ≥60 days before the Screening Visit or confirmed via sperm analysis) or must agree to use protocol-specified contraception from the Screening Visit through 60 days after the final dose of study drug
• Other exclusion criteria per protocol

Where it is running

• Mayo Clinic — Scottsdale, Arizona, United States
• University of Arizona — Tucson, Arizona, United States
• Cardiology and Medicine Clinic — Little Rock, Arkansas, United States
• JEHM — La Mesa, California, United States
• Axis Clinical Trials — Los Angeles, California, United States
• JEHM — National City, California, United States
• Valley Clinical Trials — Northridge, California, United States
• Stanford University — Palo Alto, California, United States
• Harbor UCLA Medical Center — Torrance, California, United States
• Aurora Denver Cardiology — Denver, Colorado, United States
• South Denver Cardiology Associates — Littleton, Colorado, United States
• Holy Cross Hospital — Fort Lauderdale, Florida, United States
• New Generation of Medical Research — Hialeah, Florida, United States
• East Coast Institute for Research — Jacksonville, Florida, United States
• PCRS Network, LLC — Miami, Florida, United States
• Broward Research Center — Pembroke Pines, Florida, United States
• Progressive Medical Research — Port Orange, Florida, United States
• St. Luke's Regional Medical Center — Boise, Idaho, United States
• Northwestern University — Chicago, Illinois, United States
• Unity Point Health - Methodist Hospital — Peoria, Illinois, United States
• Franciscan Physician Network - Indiana Heart Physicians — Indianapolis, Indiana, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• Lousiana Heart Center — Bogalusa, Louisiana, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• Arizona Arrhythmia Research Center — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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