MRS and Medication Response: A Pilot Study
Stopped early
Conditions studied: Major Depressive Disorder, Major Depressive Episode, Major Depressive Disorder, Recurrent, Major Depression Mild, Major Depression Moderate, Major Depression Severe
In brief
We hope to demonstrate that magnetic resonance spectroscopy can detect brain concentration levels of paroxetine (Paxil) or citalopram (Celexa) or escitalopram (Lexapro) in depressed patients.
Key facts
- Study ID
- NCT03254342
- Run by
- Stanford University
- People needed
- 3
- Starts
- 2013-08-06
- Expected to finish
- 2020-08-31
- Last updated by the study team
- 2021-08-19
Who can join
Age: 21 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- DSM diagnosis of Major Depressive Disorder
- Taking paroxetine [(Paxil) or citalopram (Celexa) or escitalopram (Lexapro)]for at least 6 weeks
- Between 21 - 75 years of age.
- Taking a stable dose of paroxetine [(Paxil) or citalopram (Celexa) or escitalopram (Lexapro)] for at least the 2 weeks prior to the imaging session
- Healthy controls:
- Between 21 - 75 years of age.
- Have a 21-item HAM-D score of less than or equal to 5.
- No current, or history of any Axis I disorder.
- Identify exclusion criteria.
- Exclusion criteria are as follows:
- Contraindications for an MRI exam. These includes biomedical devices such as pacemakers, aneurysm clips, prostheses, and other metallic objects embedded in the body such as bullets, buckshot, shrapnel, and any metal fragments from working around metal.
- Current pregnancy or lactation.
- Patients with claustrophobia.
- History, or current Axis I or Axis II disorders
- Active unstable medical problems, as confirmed by screening procedures
- Diagnosed with any autoimmune disease, (e.g., rheumatoid arthritis, Lupus, MLS).
- Chronic use of steroids or opiates.
- Positive urine toxicology screen for illicit substances of abuse.
Where it is running
- Stanford University Psychiatry and Biobehavioral Sciences — Stanford, California, United States
Full record on ClinicalTrials.gov
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