Translational Approaches to Septic Cardiomyopathy

Status unconfirmed

Conditions studied: Cardiomyopathies, Sepsis, Septic Shock

In brief

This translational study will assess the association between septic cardiomyopathy (measured via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and (b) the behavior of cardiomyocytes derived from inducible pluripotent stem cells.

Key facts

Study ID

NCT03252613

Run by

Samuel Brown

People needed

24

Starts

2017-05-19

Expected to finish

2019-10-27

Last updated by the study team

2018-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years of age Admitted to the ICU
• SEPSIS PATIENTS:
• Sepsis patients must have:
• Suspected or confirmed infection AND
• Organ dysfunction as defined by a SOFA >= 2 above baseline (if no baseline data available, SOFA assumed to be 0)
• OR
• SEPTIC SHOCK PATIENTS:
• AFTER INFUSION OF 20ML/KG CRYSTALLOID OR EQUIVALENT, septic shock patients must have:
• Suspected or confirmed infection AND
• Lactate > 2 mmol/L AND
• Receiving vasopressors
• EXCLUSION CRITERIA Known pregnancy Primary diagnosis of acute coronary syndrome Known preexisting heart disease Known severe valvular disease (regurgitation or stenosis)
• Major cardiac dysrhythmia such as:
• Ventricular tachycardia (V-tach)
• Ventricular Fibrillation (V-fib)
• Third degree heart block (complete hear block or complete AV block)

Where it is running

• Stanford University — Stanford, California, United States
• Intermoutain Medical Center — Murray, Utah, United States

Full record on ClinicalTrials.gov

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