The Effects of OMT on the Expression Patterns of Immune Cell Biomarkers

Stopped early · Not applicable

Conditions studied: Osteopathic Manipulation, Low Back Pain, Biomarkers

In brief

This study intends to understand the effects of osteopathic manipulative treatment (OMT) on the expression patterns of 60 immune cell biomarkers in the peripheral blood mononuclear cells (PBMC) of each participant, before and after intervention - OMT or seated control. This study will utilize participants with a history of low back pain (LBP), and will identify and validate those immune cell biomarkers that change in most participants after OMT, by using the novel protein subcellular localization (PSL) microarray technology. This study intends to uncover the important immune cells affected by OMT techniques, therefore to uncover the molecular mechanisms of OMT.

Key facts

Study ID

NCT03250312

Run by

A.T. Still University of Health Sciences

People needed

40

Starts

2017-09-13

Expected to finish

2019-08-31

Last updated by the study team

2020-01-13

Who can join

Age: 20 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• experienced at least one or more episodes of LBP in the past two weeks
• BMI (body mass index) < 30 kg/m2
• be able to lie on my back for 30 minutes
• be able to tolerate OMT

You may not qualify if…

• Have spinal manipulation in the 48 hours prior to the study date
• Have corticosteroids in the 2 weeks prior to the study date
• Have nonsteroidal anti-inflammatory medication in the 48 hours prior to the study data
• Have spinal surgery in the lumbar or low thoracic spine
• Have congenital deformities of the lumbar spine such as spina bifida

Where it is running

• A. T. Still University of Health Sciences — Kirksville, Missouri, United States

Full record on ClinicalTrials.gov

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