Flavonoids, Exercise, Gut-Derived Phenolics

Completed · Not applicable · Has a placebo group

Conditions studied: Exercise and Gut-derived Phenolics

In brief

PURPOSE: 1. PRIMARY: Using a randomized, parallel group design, this investigation will determine if the combination of 2-weeks polyphenol supplementation (using the Reoxcyn flavonoid supplement in capsule form) and one acute 45-minute brisk walking bout enhances the translocation of gut-derived phenolics into the circulation. A comparator group of runners (N=20) ingesting the flavonoid supplement for two weeks will be included (2.5 h run, 70% VO2max). 2. SECONDARY: Data from this study will determine if 2-weeks supplementation of the Reoxcyn flavonoid supplement is a sufficient time period to increase circulating levels of gut-derived phenolics, extending data collected from the previous 12-week community trial. HYPOTHESIS: We hypothesize that an acute 45-minute brisk walking exercise bout (60% VO2max) following 2 weeks of increased polyphenol intake will be a sufficient exercise stimulus to increase gut permeability and the movement of gut-derived phenolics into circulation. If this hypothesis is confirmed, these data would have broad public health appeal, demonstrating that the combination of brisk walking and increased polyphenol intake augments circulating levels of health-restoring small phenolic molecules derived from bacterial breakdown in the colon.

Key facts

Study ID

NCT03249571

Run by

Appalachian State University

People needed

100

Starts

2017-06-05

Expected to finish

2017-08-30

Last updated by the study team

2017-10-11

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Females and males, 18 to 50 years of age
• Body mass index <35 kg/m2 (i.e., not moderately or severely obese)
• Body weight of 100 pounds and greater
• Willing to consume during the study less than 5 servings/day fruits and vegetables, less than 2 cups/day coffee, and no green tea.
• Willing to avoid use of non-steroidal anti-inflammatory drugs (NSAIDs), and all dietary and herbal supplements for the 2-week study (and starting one week prior to the study).
• Walkers: Regular history of walking (>100 min/week totaling all walking, both short or long duration episodes) and capable of walking 45 min briskly on a treadmill
• Runners: History of participating in 10 km to 42.2 km races and capable of running for 2.5 h on a treadmill.
• Non-smoker.
• Generally healthy and without chronic disease including cardiovascular disease (e.g., heart disease, stroke), cancer, type 1 and 2 diabetes, rheumatoid arthritis.
• Willing to maintain normal physical activity and diet habits, and make no formal attempts to lose weight during the 2-week study.

You may not qualify if…

• Use of aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) [e.g. ibuprofen (Advil, Motrin, Nuprin), naproxen (Aleve, Naprosyn), and COX-2 inhibitors (Celebrex)] within one week prior to the study, and/or intent to use these drugs during the 2-week period of the study.
• Regular use of fish oil supplements, omega 3 supplements, or omega 3-based drugs (Lovaza, etc.) during the past one to two weeks and plans to use these supplements during the study.
• Pregnant or breastfeeding.
• Currently on a weight reducing plan or using weight-loss medications (e.g., selective serotonin reuptake inhibitors, steroids, Ritalin, appetite suppressors, Xenical, Diethylpropion), and plans to continue during the 2-week period of the study.
• Regular use of large dose nutrient, herbal, and dietary supplements during the past one to two weeks, and plans to use these during the 2-week period of the study.

Where it is running

• North Carolina Research Campus, Human Performance Lab — Kannapolis, North Carolina, United States

Full record on ClinicalTrials.gov

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