Human Brain Adaptation to Chronic Pain and Its Effects on Opioid Use

Stopped early

Conditions studied: Pain, Chronic, Opioid Use

In brief

The purpose of this study is to determine if the research results obtained in animal models of pain - that show that being in pain for some time increases opioid use beyond what is expected to treat the current pain - also apply to patients with chronic pain.

Key facts

Study ID

NCT03248765

Run by

Washington University School of Medicine

People needed

10

Starts

2017-08-30

Expected to finish

2020-09-11

Last updated by the study team

2020-10-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65
• With and without history of chronic muscle-skeletal pain *
• Scheduled to undergo elective abdominal surgery requiring overnight hospital admission
• Opioid naïve**
• Willing to comply with study procedures as outlined in the protocol
• Willing and able to provide informed consent
• Having an email address and access to a computer or electronic tablet

You may not qualify if…

• Current use of opioids (includes ANY use in past 3 months)
• Cancer diagnosis
• Patient presenting the following documented conditions:
• Untreated psychosis Current suicidal ideation Current substance abuse

Where it is running

• Washington University in St Louis School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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