Fluorescein Angiography With a Full-dose Versus a Half-dose of Intravenous Fluorescein
Paused · Phase 4
Conditions studied: Fluorescein Angiography
In brief
Fluorescein angiography is a common procedure used in ophthalmology to diagnose and monitor diseases of the eye. The standard dose of fluorescein dye used in fluorescein angiography is 500mg. It is common practice to give patients who have previously had an adverse reaction to fluorescein dye a half-dose, or 250mg, of fluorescein. It has been determined by our institution that anecdotally, there is no difference in image quality between the images created by a half-dose of fluorescein versus a full dose of fluorescein. Therefore, this study seeks to determine whether these doses are actually equivalent in terms of image quality. Patients who consent to participate in the study will be randomized to receive either a half or a full dose of intravenous fluorescein, and their images will be compared subjectively using a masked team of retinal surgeons and residents. We hypothesize that there will be no significant difference between the images obtained using a half-dose versus a full dose of intravenous fluorescein.
Key facts
- Study ID
- NCT03244982
- Run by
- Kresge Eye Institute
- People needed
- 79
- Starts
- 2018-04-05
- Expected to finish
- 2020-12-01
- Last updated by the study team
- 2020-03-16
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients scheduled for fluorescein angiography at Kresge Eye Institute.
You may not qualify if…
- Patients with known major profusion defects on fluorescein angiography.
- Patients with prior adverse reactions to fluorescein angiography.
- Patients with significant photophobia as judged by the photographer.
- Patients with visually significant cataracts.
Where it is running
- Kresge Eye Institute — Detroit, Michigan, United States
Full record on ClinicalTrials.gov
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