Comparing the Effects of Lactated Ringers and Normal Saline in Acute Pancreatitis

Completed · Not applicable

Conditions studied: Pancreatitis

In brief

Acute pancreatitis is increasingly common diagnosis in children. Most of the guidelines related to the details of management of acute pancreatitis are extrapolated from the adult literature. There is only limited data regarding management of acute pancreatitis in children. The mainstay of management is bowel and pancreatic rest with significant fluid support to minimize the effect of the cytokines on the pancreas and other organs. The standard fluid choices are Lactated Ringer's solution (LR) and normal saline (NS). Currently, both LR and NS are used at the discretion of the treating physician as the standard of care for acute pancreatitis. The investigators hope to examine the question of ideal fluid choice for fluid resuscitation in children with acute pancreatitis by assessing recovery time in the context of measured inflammatory markers and SIRS status at 24 and 48 hours after admission. The ideal fluid choice in the initial resuscitation of acute pancreatitis has not been effectively evaluated before in the pediatric population. Even if there is no statistically significant difference between the two fluid options, this trial will still provide clinically significant information.

Key facts

Study ID

NCT03242473

Run by

Children's Hospital Medical Center, Cincinnati

People needed

79

Starts

2014-12-01

Expected to finish

2020-10-23

Last updated by the study team

2021-08-17

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 0-18 years diagnosed with acute pancreatitis in the emergency department or inpatient ward at Children's Hospital of The King's Daughters or one of the affiliated institutions participating in the study.

You may not qualify if…

• Patients greater than 18 years of age
• Patients who are not diagnosed with acute pancreatitis
• Patients who have any previous history of acute pancreatitis, past medical history of underlying illness including congenital heart disease, chronic lung disease, or renal failure
• Patients who have any of the following: hyperkalemia, systemic acidosis, acute dehydration, extensive tissue breakdown, adrenal insufficiency, concomitant use of potassium-sparing diuretics, use of extended-release preparations in patients with esophageal compression caused by an enlarged left atrium, hypersensitivity to sodium chloride, hypernatremia, or fluid retention
• Patients who are pregnant females
• Patients who have additional comorbidities at time of admission that would prevent adequate treatment with the methods described above will be excluded

Where it is running

• Children's National Health System — Washington D.C., District of Columbia, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of The King's Daughters — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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