Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury

Completed · Not applicable · Has a placebo group

Conditions studied: Contrast-induced Acute Kidney Injury

In brief

This a prospective, double-blind, sham-controlled, randomized clinical trial to study the effects of remote ischemic preconditioning on acute kidney injury, vascular and renal biomarkers in patients with non-ST elevation myocardial infarction and unstable angina undergoing coronary angiography and/or percutaneous coronary intervention.

Key facts

Study ID

NCT03236441

Run by

Oladipupo Olafiranye, MD, MS

People needed

110

Starts

2018-03-06

Expected to finish

2024-02-28

Last updated by the study team

2025-01-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient with non-ST elevation myocardial infarction or unstable angina
• Referral for cardiac catheterization and percutaneous coronary intervention
• Contrast-induced acute kidney injury risk score of ≥11

You may not qualify if…

• Inability to give informed consent
• unstable blood pressure (systolic blood pressure > 200 or <90 mmHg)
• History of allergy to contrast media
• Peripheral vascular disease of upper limb
• Renal disease requiring dialysis
• Placement of arteriovenous fistula and arteriovenous graft

Where it is running

• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
• VA Pittsburgh Healthcare System — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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