A Prospective Trial of Behavioral Therapy for Chronic Cough
Status unconfirmed · Not applicable
Conditions studied: Cough
In brief
This study seeks to explore whether heart rate variability (HRV) biofeedback can be effective in the treatment of chronic cough. Chronic cough has many causes, including asthma, postnasal drip, and gastroesophageal reflux disease (GERD), each with a specific treatment. However, among a subset of cough patients, no clear cause is found despite extensive workup, and traditional treatment methods do not provide relief. Several studies revealed less common causes of chronic cough and disordered breathing such as vagal neuropathy, paradoxical vocal fold motion, and stress. Additional research identified links between the neurological networks that produce the cough reflex and those that maintain normal breathing. HRV biofeedback is a self-regulation technique that uses computer equipment to monitor heart rate and breathing, two key functions of the autonomic nervous system. By using this non-invasive behavioral technique, cough patients can regulate their breathing and autonomic function, potentially leading to improved autonomic balance and a reduction in cough symptoms.
Key facts
- Study ID
- NCT03235466
- Run by
- University of California, San Diego
- People needed
- 45
- Starts
- 2018-02-01
- Expected to finish
- 2021-12-01
- Last updated by the study team
- 2020-12-04
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 8+ weeks of cough, Fluent English speaker, Have access to an electronic mobile device
You may not qualify if…
- On neuromodulator therapy, cardiac arrhythmia, dysphagia, prior HRVB or mindfulness, head and neck surgery of the oropharynx, neck or larynx, lung surgery, pulmonary pathology other than asthma, tourette syndrome, ACE inhibitor use, current or recent smoker.
- Added exclusion criteria as of March 2020 - history of COVID+.
Where it is running
- UCSD Center for Voice and Swallowing — San Diego, California, United States (enrolling)
Full record on ClinicalTrials.gov
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