Effects of Altitude on Single-Breath Diffusing Capacity for Carbon Monoxide

Completed

Conditions studied: COPD

In brief

The purpose of this study is to further understand the effects of altitude on the physiology of gas exchange in the pulmonary microcirculation in normal subjects and in people with chronic obstructive pulmonary disease (COPD) measured as the single-breath diffusing capacity for carbon monoxide (DLCOsb). The study will determine a mathematical formula to allow for altitude corrections in both study populations to be used clinically in pulmonary labs.

Key facts

Study ID

NCT03235297

Run by

Intermountain Health Care, Inc.

People needed

23

Starts

2017-08-10

Expected to finish

2019-07-01

Last updated by the study team

2020-02-12

Who can join

Age: 20 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 20- 80 years
• Subjects must be either healthy or have been diagnosed with COPD

You may not qualify if…

• Anemia (hemoglobin < 10.0 g/dL)
• Carboxyhemoglobin > 3%
• Active smoking
• Heart disease or heart failure
• Pulmonary hypertension
• COPD exacerbation
• Pneumothroax within 6 months
• Bullous emphysema on chest imaging (Chest X-ray or CT)
• Supplemental oxygen use
• Diabetes mellitus
• Alcohol dependence
• Non-English speaking

Where it is running

• Intermountain Medical Center — Murray, Utah, United States

Full record on ClinicalTrials.gov

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