Dose Escalated Proton Beam Therapy or Photon Therapy for Esophageal Cancer

Withdrawn before enrolling · Phase 2

Conditions studied: Esophageal Cancer

In brief

This study will evaluate if proton beam therapy as part of chemoradiation results in a decrease in diffusion lung capacity of carbon monoxide (DLCO) compared to photon radiation therapy for esophageal carcinoma. A secondary objective is to determine effects on cardiac function, quality of life, and compare acute and late toxicities.

Key facts

Study ID

NCT03234842

Run by

University of Florida

People needed

0

Starts

2017-10-30

Expected to finish

2018-12-11

Last updated by the study team

2018-12-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must be at least 18 years at the time of consent.
• Pathologically confirmed esophageal adenocarcinoma or squamous cell. carcinoma of the thoracic esophagus or esophagogastric junction.
• Patient's preliminary cancer stage, according to the AJCC 7th edition staging, must be cT1b-T4, N0-N3.

You may not qualify if…

• Patients with cervical esophageal carcinoma.
• Prior radiotherapy with fields overlapping the current esophageal cancer.
• Patients with cT1a disease.
• Patients with evidence of tracheoesophageal fistula must undergo bronchoscopy to exclude fistula.
• Patients with distant metastatic disease.

Where it is running

• University of Florida Proton Therapy Institute — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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