World Trade Center Kidney-Link

Completed

Conditions studied: Chronic Kidney Diseases, Obstructive Sleep Apnea

In brief

This study focuses on the prevalence and identification of kidney disease among participants of the WTC Health Program and the study team are planning to assess kidney disease in a multi-factorial manner. The first aim of this study is to correlate kidney dysfunction with 9/11 exposure, and the study team predicts that exposure to 9/11 is an independent risk factor in kidney disease among the WTC Health Program participants. Secondly, the study team proposes that a well-established WTC-related condition, obstructive sleep apnea (OSA), is independently associated with kidney disease. In addition, the study team believe there is a temporal causative relationship between evidence of kidney disease and the severity of OSA. Finally, the last aim is to further identify and explore potential mechanisms and phenotypes of kidney disease in participants of the WTC Health Programs. Regardless of whether the analyses support or reject these hypotheses, the findings will be of equally great public health importance. Successful completion of the proposed research would address a critical knowledge gap regarding the risk of kidney damage among this group of patients, and would inform future mechanistic studies with the potential to impact prevention.

Key facts

Study ID

NCT03234530

Run by

Icahn School of Medicine at Mount Sinai

People needed

555

Starts

2017-11-01

Expected to finish

2021-06-01

Last updated by the study team

2021-06-09

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Exposed Group: - Adult patients (35 to 75 years)
• Enrolled or was seen at any of the WTC Clinical Centers of Excellence
• Unexposed Group: - Adult patients (35 to 75 years)
• Lived or worked in NYC at least 10 years since 9/11/01 but were not exposed to the the dust at Ground Zero (not living in proximity of Ground Zero, nor involved in the rescue and recovery at Ground Zero
• Registry Part: - Adult patient (18 to 75 years)
• Enrolled or was seen at any of the WTC Clinical Centers of Excellence or WTC Environmental Health Centers
• With a diagnosis of any Kidney Injury or disease after 9/11/01

You may not qualify if…

• Patients below 18 years of age
• Individuals with an occupation involving chronic exposure to inhaled particulate matter (e.g. iron/steel workers and sand hog workers)
• For the registry part, patients with kidney disease prior to 9/11/01

Where it is running

• Icahn School of Medicine at Mount Sinai — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.