MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)

Completed · Phase 2

Conditions studied: Complicated Urinary Tract Infection, Pyelonephritis

In brief

This study aims to evaluate the safety and tolerability of MK-7625A (ceftolozane/tazobactam) compared with that of meropenem in pediatric participants with cUTI, including pyelonephritis.

Key facts

Study ID

NCT03230838

Run by

Merck Sharp & Dohme LLC

People needed

134

Starts

2018-04-26

Expected to finish

2020-12-03

Last updated by the study team

2023-05-06

Who can join

Age: 0 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Has a legally acceptable representative who provides documented informed consent / assent for the trial.
• Ages from birth (defined as >32 weeks gestational age and ≥7 days postnatal) to <18 years of age.
• Requires IV antibacterial therapy for the treatment of cUTI.
• Have a pretreatment baseline urine culture specimen obtained within 48 hours before the start of administration of the first dose of study treatment and preferably prior to administration of any potentially therapeutic antibiotics.
• Has pyuria.
• Has clinical signs and/or symptoms of cUTI at the Screening Visit.
• Is not of reproductive potential; but if of reproductive potential agrees to avoid becoming pregnant or impregnating a partner during screening, while receiving study treatment and for at least 30 days after the last dose of study treatment.
• Female of reproductive potential is not pregnant, and not planning to become pregnant within 30 days of the last day of treatment administration; and is nonlactating.

You may not qualify if…

• Is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 30 days prior to the first dose of study treatment in this current trial.
• Has previously participated in any trial of ceftolozane or ceftolozane/tazobactam or has enrolled previously in the current trial and been discontinued.
• Has a history of any moderate or severe hypersensitivity (e.g.anaphylaxis), allergic reaction, or other contraindication to any of the following: β-lactam antibiotics (e.g, penicillins, cephalosporins, and carbapenems), β-lactamase inhibitors (e.g. tazobactam, sulbactam, clavulanic acid, avibactam), or metronidazole.
• Has a history of a cUTI within the past 1 year prior to randomization known to be caused by a pathogen resistant to either IV study treatment.
• Has a concomitant infection at the time of randomization that requires nonstudy systemic antibacterial therapy in addition to IV study treatment or oral step -down therapy.
• Has received potentially therapeutic antibacterial therapy for a duration more than 24 hours during the 48 hours preceding the first dose of study treatment.
• Has any of the following: a) intractable UTI or pyelonephritis infection at baseline that the Investigator anticipates would require more than 14 days of study treatment; b) confirmed fungal urinary tract infection at time of randomization; c) permanent indwelling bladder catheter or instrumentation including nephrostomy; d) current urinary catheter that is not scheduled to be removed before the end of all study treatment; e) complete, permanent obstruction of the urinary tract; f) suspected or confirmed perinephric or intrarenal abscess; g) documented ileal loop reflux; h) suspected or confirmed prostatitis, urethritis, or epididymitis; i) trauma to pelvis/urinary tract.
• Has moderate or severe impairment of renal function.
• Has a seizure disorder or is anticipated to be treated with divalproex sodium or valproic acid during the course of study treatment.
• Is receiving, or is expected to receive, any prohibited medications.
• Has any rapidly progressing disease or immediately life-threatening illness, including acute hepatic failure, respiratory failure, or septic shock.
• Has an immunocompromising condition.
• Has a history of malignancy ≤5 years prior to signing informed consent.
• Is planning to receive suppressive/prophylactic antibiotics with gram-negative activity after completion of study treatment.

Where it is running

• Children's Hospital of Orange County ( Site 2502) — Orange, California, United States
• Rady Children's Hospital-San Diego ( Site 2505) — San Diego, California, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago ( Site 2519) — Chicago, Illinois, United States
• Our Lady of the Lake Hospital ( Site 2512) — Baton Rouge, Louisiana, United States
• St. Louis Children's Hospital ( Site 2508) — St Louis, Missouri, United States
• SUNY Upstate Medical University Hospital ( Site 2510) — Syracuse, New York, United States
• Wake Forest Baptist Health ( Site 2520) — Winston-Salem, North Carolina, United States
• Baylor College Of Medicine ( Site 2515) — Houston, Texas, United States
• Pan and Aglaia Kyriakou Children s Hospital ( Site 0780) — Athens, Attica, Greece
• University of Athens - Aghia Sophia Childrens Hospital ( Site 0730) — Athens, Attica, Greece
• Athens University Hospital ATTIKON ( Site 0790) — Athens, Attica, Greece
• Hippokration General Hospital of Thessaloniki ( Site 0700) — Thessaloniki, Thessaloníki, Greece
• General University Hospital of Larissa ( Site 0740) — Larissa, Thessaly, Greece
• PTE AOK Klinikai Kozpont ( Site 0809) — Pécs, Baranya, Hungary
• SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 0804) — Szeged, Csongrád megye, Hungary
• SzSzBMK es Egyetemi Oktatokorhaz Josa Andras Oktatokorhaz ( Site 0808) — Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary
• Semmelweis Egyetem ( Site 0810) — Budapest, Hungary
• Heim Pal Orszagos Gyermekgyogyaszati Intezet ( Site 0801) — Budapest, Hungary
• Debreceni Egyetem Klinikai Kozpont ( Site 0803) — Debrecen, Hungary
• Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 1202) — Guadalajara, Jalisco, Mexico
• Instituto Tecnologico y de Estudios Superiores de Monterrey ( Site 1204) — Monterrey, Nuevo León, Mexico
• Instituto Nacional de Pediatria ( Site 1201) — Mexico City, Mexico
• Hospital Infantil de Mexico Federico Gomez ( Site 1203) — Mexico City, Mexico
• Wojewodzki Szpital Obserwacyjno Zakazny ( Site 1606) — Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
• Children's Hospital - Los Angeles ( Site 2509) — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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