Patterns of Neurocircuitry Activation In Severe Asthma

Completed

Conditions studied: Lung Diseases

In brief

The overall purpose of the study is to compare the patterns of neurocircuitry activation in severe asthmatics vs. mild to moderate and healthy controls. The Investigators hypothesize that neurocircuitry activation increases with asthma severity, producing different neurocircuitry patterns for severe asthmatics than those of mild to moderate asthmatics or non-asthmatics.

Key facts

Study ID

NCT03230188

Run by

University of Wisconsin, Madison

People needed

28

Starts

2017-08-01

Expected to finish

2018-06-17

Last updated by the study team

2019-01-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Currently enrolled in Severe Asthma Research Program III (2012-0571) study
• Has severe asthma
• Is a male or female with no health concerns that might affect the outcome of the study
• Provided a negative urine pregnancy test prior to visit (Females only)
• Capable and willing to grant written informed consent and cooperate with study procedures and requirements (investigator discretion)
• Is able to tolerate a simulated functional Magnetic Resonance Imaging brain scanning session
• Is able to give valid informed consent to participate by signing and dating a written consent form

You may not qualify if…

• Uses psychotropic medication that might affect function of neurocircuitry implicated in our hypotheses (at the discretion of a study physician or Co-Investigator)
• Has one or more contraindications for functional Magnetic Resonance Imaging
• Has needle phobia or claustrophobia
• Unable to distinguish specific colors used in Stroop task
• History of a diagnosed Bipolar Disorder, Schizophrenia, or Schizoaffective Disorder
• Is a pregnant or lactating female
• Has had an upper or lower respiratory infection within 1 month of the visit
• Has unstable asthma as indicated by self-report of increased symptoms or increased beta-agonist use over the 2 weeks preceding the visit
• Is a current smoker (defined as smoked within the last year) or a former smoker with a history of >5 pack years
• Any condition which, in the opinion of the investigator, might interfere with participation in the study
• Inability or unwillingness to perform required study procedures

Where it is running

• UW Madison — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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