QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
Running, not enrolling · Phase 2
Conditions studied: Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Urothelial Carcinoma, Head and Neck Squamous Cell Carcinoma, Merkel Cell Carcinoma, Melanoma, Renal Cell Carcinoma, Gastric Cancer, Cervical Cancer, Hepatocellular Carcinoma, Microsatellite Instability, Mismatch Repair Deficiency, Colorectal Cancer
In brief
QUILT-3.055 is a Phase 2b, open-label, multicohort study investigating combination immunotherapies in patients with advanced solid tumors who have previously been treated with PD-1/PD-L1 checkpoint inhibitors. The study aims to evaluate the safety and efficacy of NAI (nogapendekin alfa inbakicept) in combination with other agents like checkpoint inhibitors and cell therapies across various cancer types and treatment settings. The study includes multiple cohorts based on prior therapies and cancer types, with a focus on assessing overall response rate (ORR), overall survival (OS), and other measures of anti-tumor activity and immune response.
Key facts
- Study ID
- NCT03228667
- Run by
- ImmunityBio, Inc.
- People needed
- 40
- Starts
- 2018-12-11
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-01-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alaska Clinical Research Center — Anchorage, Alaska, United States
- Genesis Cancer Center — Hot Springs, Arkansas, United States
- Chan Soon-Shiong Institute for Medicine — El Segundo, California, United States
- MemorialCare Health System — Fountain Valley, California, United States
- Glendale Adventist Medical Center — Glendale, California, United States
- University of Southern California Norris Comprehensive Cancer Center — Los Angeles, California, United States
- Desert Hematology Oncology Medical Group, Inc. — Rancho Mirage, California, United States
- Memorial Healthcare System — Hollywood, Florida, United States
- Miami Cancer Institute (Baptist Health South Florida) — Miami, Florida, United States
- University of Miami — Miami, Florida, United States
- Horizon Oncology Associates — Lafayette, Indiana, United States
- University of Iowa Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
- Baptist Health - Lexington — Lexington, Kentucky, United States
- Baptist Health- Louisville — Louisville, Kentucky, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Henry Ford Hospital — Detroit, Michigan, United States
- University of Minnesota - Masonic Cancer Center — Minneapolis, Minnesota, United States
- Mercy Research Joplin — Joplin, Missouri, United States
- Mercy Clinic Cancer & Hematology - Chub O'Reilly Cancer Center — Springfield, Missouri, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- St. Vincent Frontier Cancer Center (SCL) — Billings, Montana, United States
- Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- University of Rochester — Rochester, New York, United States
- Cleveland Clinic - Main Site — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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