Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease
Stopped early · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Huntington's Disease
In brief
PRECISION-HD2 is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of WVE-120102 in adult patients with early manifest Huntington's disease (HD) who carry a targeted single nucleotide polymorphism (SNP) rs362331 (SNP2).
Key facts
- Study ID
- NCT03225846
- Run by
- Wave Life Sciences USA, Inc.
- People needed
- 88
- Starts
- 2017-07-17
- Expected to finish
- 2021-05-10
- Last updated by the study team
- 2022-04-25
Who can join
Age: 25 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California San Diego — La Jolla, California, United States
- University of California Davis Medical Center — Sacramento, California, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- The Ohio State University — Columbus, Ohio, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- Westmead Hospital — Sydney, New South Wales, Australia
- Royal Brisbane & Women's Hospital — Herston, Queensland, Australia
- Royal Melbourne Hospital — Carlton, Victoria, Australia
- Monash Health — Clayton, Victoria, Australia
- Alfred Health — Melbourne, Victoria, Australia
- Calvary Health Care Bethlehem — Parkdale, Victoria, Australia
- North Metropolitan Health Service — Perth, Western Australia, Australia
- University of Alberta — Edmonton, Alberta, Canada
- Centre For Movement Disorders — Toronto, Ontario, Canada
- Centre Hospitalier de l-Universite de Montreal — Montreal, Quebec, Canada
- Aarhus Universitets Hospital — Aarhus N, Denmark
- Rigshospitalet — Copenhagen, Denmark
- Odense University Hospital and University of Southern Denmark — Odense, Denmark
- Hospital Henri Mondor — Créteil, France
- Institut du Cerveau et de la Moelle Epinière — Paris, France
- George-Huntington-Institut GmbH — Münster, Germany
- Szpital Sw. Wojciecha — Gdansk, Poland
- Instytut Psychiatrii i Neurologii — Warsaw, Poland
- Royal Devon and Exeter Hospital NHS Trust — Exeter, Devon, United Kingdom
- Queen Elizabeth University Hospital - PPDS — Glasgow, Glasgow City, United Kingdom
Full record on ClinicalTrials.gov
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