Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure

Completed

Conditions studied: Acute Respiratory Distress Syndrome, ARDS, Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Respiratory Distress Syndrome, Shock Lung, Severe Acute Respiratory Syndrome

In brief

This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a proven standardized lung protective ventilation protocol in the new electronic medical record system iCentra across all Intermountain Healthcare hospitals. Approximately 14,000 records will be accessed for this study from a database of mechanically ventilated patients established for quality improvement purposes. The investigators hypothesize that implementation of a standardized computerized lung protective ventilation protocol across all Intermountain Healthcare hospitals will be feasible, will decrease initial tidal volumes to the target 6 ml/kg PBW, and will improve outcomes. The objectives of this study are to: * Determine if the implementation of lung protective ventilation (with a 6 ml/kg PBW tidal volume ventilation protocol on initiation of mechanical ventilation) improves outcomes in patients with acute respiratory failure requiring mechanical ventilation * Determine if the implementation of lung protective ventilation (with a 6 ml/kg PBW tidal volume ventilation protocol on initiation of mechanical ventilation) improves outcomes in the sub-group of patients with the acute respiratory distress syndrome (ARDS) * Measure compliance with the implementation of a computerized lung protective ventilation protocol at 12 Intermountain Healthcare hospitals

Key facts

Study ID: NCT03225807
Run by: Intermountain Health Care, Inc.
People needed: 8692
Starts: 2016-03-01
Expected to finish: 2022-12-01
Last updated by the study team: 2024-03-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Initiation of mechanical ventilation in the emergency department or intensive care unit at an Intermountain Healthcare hospital
Age ≥ 18 years

You may not qualify if…

Transition to comfort care in the emergency department or on the same day of admission to the ICU
Death on the same day of admission to the emergency department or ICU

Where it is running

Colin Grissom — Murray, Utah, United States

Full record on ClinicalTrials.gov

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