Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

Recruiting now

Conditions studied: Cirrhosis

In brief

To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.

Key facts

Study ID

NCT03225677

Run by

The Cleveland Clinic

People needed

20

Starts

2017-08-03

Expected to finish

2027-09-30

Last updated by the study team

2025-12-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The diagnosis of cirrhosis based on liver biopsy and/or clinical, biochemical, and imaging criteria.
• Patients with Child Pugh score from A5- to B7
• Control group: Subject in control group should have serum ALT and AST within normal range.
• Exclusion Criteria for both groups (cirrhotic and control) are:
• diabetes
• cancer
• kidney failure
• pregnancy
• recent surgery (bowel resection or Gastric bypass operation)
• Advanced cardiac or pulmonary disease
• patient with thyroid disease \& Coagulopathy ( INR >1.4 and platelet count <80,000/ml)

Where it is running

• Cleveland Clinic Foundation — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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