Mechanisms of Refractory Hypertension (Reserpine)

Completed · Phase 2

Conditions studied: Refractory Hypertension

In brief

The study is deigned to determine if refractory hypertension is attributable to heightened sympathetic tone by quantifying the antihypertensive benefit of reserpine, a sympatholytic agent, in patients failing other classes of antihypertensive agents.

Key facts

Study ID

NCT03223272

Run by

University of Alabama at Birmingham

People needed

7

Starts

2015-07-23

Expected to finish

2020-01-31

Last updated by the study team

2021-11-30

Who can join

Age: 19 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adult with refractory hypertension defined as uncontrolled office blood pressure with use of 5 or more hypertensive agents, including a thiazide diuretic and spironolactone

You may not qualify if…

• congestive heart failure (EF 40%)
• chronic kidney disease (GFR <40 ml/min/1.73 mm)
• stroke and/or myocardial infarction or acute CHF exacerbation within last 3 months
• ongoing depression
• active peptic ulcer disease
• bradycardia <50 beats per minute
• 2nd or 3rd degree heart block
• known intolerance of reserpine
• use of digoxin or tricycle antidepressants

Where it is running

• UAB — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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