Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients

Completed · Not applicable

Conditions studied: Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxia

In brief

Humidified Nasal High-flow with Oxygen (HNHF-O2) therapy has been reported to have acute beneficial effects in patients with hypoxemic respiratory failure who have been hospitalized. The usefulness of this therapy in the outpatient setting is unproven. This pilot study will test the feasibility of using this therapy in the outpatient setting and its effects on sleep.

Key facts

Study ID

NCT03221387

Run by

Temple University

People needed

30

Starts

2017-09-10

Expected to finish

2019-12-15

Last updated by the study team

2021-06-07

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• admitted to the hospital for an acute exacerbation of COPD within the past 12 weeks
• have COPD as the primary diagnosis
• have smoked > 10 pack years.
• receiving supplemental oxygen as part of their usual clinical care.
• willing to give informed consent

You may not qualify if…

• upper airway or nasal problems that prohibit the use of high flow oxygen
• current use (≤ 4 weeks of study entry) of any PAP-therapy (e.g., CPAP or NPPV)
• sleep apnea as follows: STOPBang scores ≥ 5 or STOPBang score ≥ 2 plus BMI > 35 kg/m2; or Berlin questionnaire scores suggesting high likelihood of sleep apnea with increased risk of sleep-related accident (e.g., occupation as a commercial driver or pilot);
• excessive daytime sleepiness (i.e., either of High (>15) score on the Epworth Sleepiness Scale or "fall asleep" accident or "near miss" accident in prior 12 months).

Where it is running

• Temple University Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.