A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea

Completed · Not applicable

Conditions studied: Pellucid Marginal Corneal Degeneration, Keratoconus, Keratectasia

In brief

The purpose of this research study is to find out if the new Brillouin Ocular Scanner can measure the variation (difference) of the corneal elastic changes involved in the onset of corneal ectasia, induced by LASIK surgery and cornea collagen crosslinking (CXL) treatment. Ectasia refers to the thinning and bulging of the cornea and results in severe vision degradation (loss), which may occur because of a progressive disease (keratoconus) or because of LASIK surgery. It is believed that the structural weakening of the cornea plays a major role in developing ectasia. CXL is a treatment that is able to halt the progression of ectasia. The Brillouin Ocular Scanner is a technique based on the principles used in the laser speed measuring of a car (radar gun). When laser light illuminates a moving sample, a portion of the light slightly changes color. In our body, e.g in eye and corneal tissue, very weak sound waves are naturally present and they can induce a similar color shift. Measuring this color shift with a sensitive light color meter (spectrometer), we will measure the sound speed in the tissue.

Key facts

Study ID

NCT03220529

Run by

Massachusetts General Hospital

People needed

85

Starts

2016-11-01

Expected to finish

2020-09-01

Last updated by the study team

2022-08-02

Who can join

Age: 15 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects with healthy cornea
• Patients with mild, moderate, or advanced keratoconus
• Subjects diagnosed with PMD
• Patients before and after LASK surgery
• Patients with keratoconus before and after collagen crosslinking treatment

You may not qualify if…

• Normal volunteer group: presbyopia and/or cataract
• Keratoconus subjects group: corneas with scars developed, received any ocular surgery, such as laser vision correction surgeries or CXL treatment
• Subjects diagnosed with PMD: excludes corneas received any ocular surgery, such as laser vision correction or CXL treatment
• Patients before and after LASK surgery Corneas received priori ocular surgeries, taking any ocular medications except season allergy medicine such as artificial tears

Where it is running

• Massachusetts Eye and Ear Infirmary — Boston, Massachusetts, United States
• Institute for Refractive and Ophthalmic Surgery — Zurich, Switzerland

Full record on ClinicalTrials.gov

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