Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements?

Completed · Phase 4

Conditions studied: Arthropathy of Hip

In brief

During many surgeries, increased muscle tension makes it harder for the surgeon to expose the site of surgery and work within the incision. Neuromuscular blockade (NMB) drugs such as Vecuronium bind to neurotransmitter (acetyl choline) receptors at the neuromuscular junction, blocking their action and producing muscle relaxation. This muscle relaxation allows easier retraction of muscle tissues and manipulation of structures in the wound. Improved surgical conditions are likely to result in improved patient outcomes. While increased depths of NMB have been shown to optimize surgical conditions during intra-abdominal and retroperitoneal procedures, the impact of NMB depth has not been reported for orthopedic surgeries.1 To address this, we propose to study the effect of NMB depth on surgical conditions during total hip replacement (THR).

Key facts

Study ID

NCT03219294

Run by

Craig Curry

People needed

116

Starts

2017-05-01

Expected to finish

2018-05-01

Last updated by the study team

2019-09-18

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists (ASA) Physical status 1-3
• age 50-75
• English speaking
• able to provide informed consent
• BMI equal to less than 30
• non-emergent THR by anterolateral minimally invasive non-cemented total hip arthroplasty

You may not qualify if…

• Revision surgery
• Bilateral THR
• ASA 4+
• age less than 50 or greater than 75
• BMI greater than 30
• unable to provide informed consent
• women taking oral contraceptives (Sugammadex used for reversal interferes with their efficacy
• contraindications to general inhalation anesthesia (such as malignant hyperthermia)
• contraindications to NMB (known allergy to NMB)
• chronic kidney disease

Where it is running

• Maine Medical Center — Portland, Maine, United States

Full record on ClinicalTrials.gov

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