Metabolic Effects of Differential Organ Growth Rates

Completed

Conditions studied: Resting Energy Expenditure

In brief

Young children have a high resting energy expenditure (REE) relative to their body weight and metabolically active compartment, fat-free mass (FFM). Both body weight and FFM are, however, metabolically heterogeneous and include organs and tissues varying widely in specific metabolic rate (i.e., organ REE/kg/d). One prevailing hypothesis is that most, if not all, of the higher REE observed in young animals and children compared to adults can be accounted for by a larger proportion of high metabolic rate components such as brain, liver, and heart..

Key facts

Study ID

NCT03219229

Run by

Columbia University

People needed

49

Starts

2004-02-14

Expected to finish

2007-02-20

Last updated by the study team

2017-07-18

Who can join

Age: 7 and older, up to 11. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• Aged from 7-11 years
• Pre-pubertal (based on Tanner staging)
• Africa-American, Asian, and Caucasian (by self-report of all 4 grandparents of same race group)

You may not qualify if…

• Actively involved in a weight management program
• Have co-morbidities of obesity (Blounts disease, hypertension, diabetes; sleep apnea)
• Have entered puberty
• Precocious puberty
• Have known metabolic abnormalities
• Were born prematurely, or were small or large for gestational age
• Lean individuals who have a family history (parents or siblings) of obesity or Type 2 diabetes
• Current or previous significant use of any medication known to affect any of the variables being measured

Where it is running

• Dympna Gallagher — New York, New York, United States

Full record on ClinicalTrials.gov

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