Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study

Recruiting now

Conditions studied: Chronic Traumatic Encephalopathy

In brief

to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre Concussion Project at the Toronto Western Hospital with the consent and full knowledge of their families and doctors. However, it is possible to participate in the research without agreeing to a brain donation. The Project Team is specifically attempting a clinical-MRI-brain tissue research analysis to determine the exact mechanism of the damage to brain tissue following repeated concussions. This condition is known as chronic traumatic encephalopathy (CTE), and shows an abnormal protein in the brain called tau-protein.

Key facts

Study ID

NCT03218332

Run by

University Health Network, Toronto

People needed

150

Starts

2011-07-04

Expected to finish

2030-12-30

Last updated by the study team

2021-09-29

Who can join

Age: 25 and older, up to 85. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• fluent in English, and a history of multiple concussions , low exposures , or no concussions (Control group ). Determination of concussion exposure will be determined as follows: Previous concussion will be based on the player's recall of injury and defined as "an injury resulting from a blow to the head that caused an alteration in mental status and one or more of the following symptoms: headache, nausea, vomiting, dizziness/balance problems, fatigue, trouble sleeping, drowsiness, sensitivity to light or noise, blurred vision, difficulty remembering, and difficulty concentrating.

You may not qualify if…

• Neurological disorders prior to concussions (e.g.: seizure disorder); systemic illnesses known to affect the brain (e.g., diabetes and lupus); a history of psychotic disorder; known developmental disorders (e.g., attention deficit disorder, dyslexia); history of migraines; and, active engagement in litigation.

Where it is running

• Canadian Concussion Centre, Toronto Western Hospital, University Health Network — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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