MEDI-551 as Maintenance Therapy After Allogeneic Stem Cell Transplant in Multiple Myeloma

Stopped early · Phase 2

Conditions studied: Multiple Myeloma

In brief

Determine the progression free survival of high-risk or relapsed Multiple Myeloma (MM) patients undergoing non-myeloablative bone marrow allogeneic transplantation (NM-AlloSCT) followed by maintenance therapy with MEDI-551.

Key facts

Study ID

NCT03218163

Run by

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

People needed

1

Starts

2017-09-27

Expected to finish

2018-04-15

Last updated by the study team

2019-01-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Previous diagnosis of MM based on standard criteria as defined in Appendix A (Diagnostic Criteria for MM). Diagnostic studies need not be performed within 30 days of registration;
• Patients must meet one of the disease criteria outlined in either a, b, or c:
• a. Patients with newly diagnosed high-risk MM achieving a partial response (PR) or better at the time of enrollment in response to systemic anti-myeloma therapy, which may include autologous hematopoietic stem cell transplant (HSCT).
• High risk is defined by the presence of any one of the following:
• i. High-risk chromosomal translocations by fluorescent in situ hybridization (FISH): t(4;14), t(14;16), t(14;20), del(17p), del(1p), amplification 1q ii. Myeloma Prognostic Risk Signature 70-Gene expression profiling (MyPRS GEP-70) high-risk signature either at diagnosis or at time of registration for the study iii. Lactate dehydrogenase (LDH) > 300 U/L at diagnosis iv. Plasma cell leukemia v. Relapse from prior therapy within 12 months
• b. Patients with high-risk MM with at least 1 prior progression in PR or better in response to salvage systemic anti-myeloma therapy at the time of enrollment
• c. Patients with standard risk MM with 1 prior progression within 18 months from an autologous HSCT and in very good partial remission (VGPR) or better in response to salvage systemic anti-myeloma therapy at the time of enrollment.
• Patients must have a suitable first-degree or second-degree related, Human leukocyte antigen (HLA)-haploidentical or HLA-matched stem cell donor. The donor and recipient must be identical at least one allele of each of the following genetic loci: HLA-A, HLA-B, HLA-Cw, major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), and Major Histocompatibility Complex, Class II, DQ Beta 1 (HLA-DQB1). A minimum match of 5/10 is therefore required, and will be considered sufficient evidence that the donor and recipient share one HLA haplotype;
• No previous AlloSCT (syngeneic HSCT permissible);
• Any previous autologous HSCT must have occurred at least 3 months prior to start of conditioning;
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-2;
• Life expectancy > 6 months;
• Adequate end organ function as measured by:
• Left ventricular ejection fraction ≥ 35% or shortening fraction > 25%
• Bilirubin ≤ 3.0 mg/dL (unless due to Gilbert's syndrome or hemolysis), and alanine aminotransferase (ALT) and aspartate transaminase (AST) < 5x upper limit of normal (ULN)
• Forced expiratory volume at one second (FEV1) and forced vital capacity (FVC) > 40% of predicted
• Not pregnant or breast-feeding;
• No uncontrolled infection. Note: Infection is permitted if there is evidence of response to medication;
• The patient must be able to comprehend and have signed the informed consent.

You may not qualify if…

• Diagnosis of any of the following cancers:
• POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M-protein) and skin changes)
• Non-secretory myeloma (no measurable protein on Serum Free Lite Assay)
• HTLV1 / HTLV2 positive
• Diagnosis of amyloidosis
• Failed to achieve at least a partial response (PR) to latest therapy;
• Known history of HIV infection;
• Systemic infection requiring treatment with antibiotics, antifungal, or antiviral agents within 7 days of registration;
• History of malignancy other than MM within 5 years of registration, except adequately treated basal or squamous cell skin cancer;
• History of serious allergy or reaction to any component of the MEDI-551 formulation that would prevent administration;
• Active hepatitis B as defined by seropositivity for hepatitis B surface antigen or patients with positive hepatitis B core antibody titers.
• Patients with hepatitis C antibody will be eligible provided that they do not have elevated liver transaminases or other evidence of active hepatitis.

Where it is running

• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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