Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Recruiting now · Phase 4

Conditions studied: Premature Ventricular Contraction (PVC)

In brief

Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.

Key facts

Study ID

NCT03218137

Run by

Weill Medical College of Cornell University

People needed

100

Starts

2017-02-13

Expected to finish

2027-12-31

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of premature ventricular contractions (PVCs)
• Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs
• Male or female between the ages of 18 and 70 years
• Capable of giving informed consent

You may not qualify if…

• Any structural heart disease
• Coronary artery disease (≥ 70% stenosis)
• Current treatment with anti-arrhythmic drugs
• Pregnant
• Asthma (if administering adenosine)

Where it is running

• Weill Cornell Medicine — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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