MAP Study: Methotrexate and Adalimumab in Psoriasis

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Psoriasis

In brief

Assess the efficacy and safety of ADA compared to ADA/MTX in patient with Psoriasis. Compare Anti-ADA antibody formation and serum ADA levels in patients on ADA compared with those on combination ADA and MTX.

Key facts

Study ID

NCT03217734

Run by

Jeffrey J Crowley MD

People needed

56

Starts

2017-04-10

Expected to finish

2018-12-31

Last updated by the study team

2019-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female adult (≥ 18yrs) with a diagnosis of moderate to severe plaque psoriasis
• Subject must have ≥ 10% body surface area involvement
• Subject must have psoriasis area and severity index (PASI) ≥12
• Subject has stable psoriasis of at least six months' duration
• Male subjects must agree to use a reliable form of birth control during the study and for 180 days after the last dose of study drug. Male subjects must not donate sperm during the study or for 180 days after the last dose of study drug. If female, subject is either not of childbearing potential (postmenopausal for at least 1 year or surgically sterile) or is of childbearing potential and is using approved method of birth control throughout study and for 180 days after last dose of study drug. Approved methods of birth control include the following:
• Condoms, sponge, foams, jellies, diaphragm, or intrauterine device (IUD)
• Hormonal contraceptives for 90 days prior to study drug administration
• A vasectomized partner
• Subject has negative PPD tuberculosis skin test at screening assessment.
• Subject must be able and willing to provide written informed consent and comply with requirements of this study protocol.

You may not qualify if…

• Diagnosis or presence of guttate, erythrodermic or pustular psoriasis
• Any previous exposure to ADA including biosimilar ADA
• Moderate to high strength topical steroids (class 4 or greater) or Vitamin D analogues within one week of study entry
• Oral systemic therapy (methotrexate, cyclosporine, apremilast, acitretin) within 8 weeks of study entry
• Previous intolerance or adverse reaction to MTX
• Phototherapy of any type within 4 weeks of study entry (narrowband UVB, psoralen-UVA, 308 nM LASER, commercial tanning units)
• IL-12/23 inhibitors (ustekinumab) and any IL-23 inhibitor (guselkumab, tildrakizumab, risankizumab) within 12 weeks of baseline
• Other biologic agents within 8 weeks of study entry
• History of chronic liver disease, hepatitis, or alcohol abuse
• Chronic use of any concomitant medication which has a significant potential for interaction with MTX (e.g. sulfa antibiotics, chronic non-steroidal anti-inflammatory (NSAID) use)
• History of tuberculosis, opportunistic infections, or any active infection at screening
• Elevated liver enzymes (AST, ALT, ≥1.5 times normal at screening)
• Serum creatinine ≥1.5 (at screening)
• Any other laboratory abnormality that would pose a concern for the investigator
• Daily alcohol use or consumption of more than four alcoholic drinks (4 ounces) in one 24 hour period
• Patients who test positive for hepatitis B or C exposure (previous vaccination to Hepatitis B is allowed)
• Cancer within the last five years is exclusionary with the exception of treated cutaneous basal cell carcinoma or squamous cell carcinoma or low-grade cervical intraepithelial neoplasia.
• Any patient that is deemed by the investigator to be at a safety risk for the intervention in this trial.

Where it is running

• Bakersfield Dermatology and Skin Cancer Medical Group — Bakersfield, California, United States
• Clinical Science Institute — Santa Monica, California, United States
• DermAssociates, PC — Rockville, Maryland, United States
• Modern Research Associates, PLLC — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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