Knee Osteoarthritis Outcome Measures in Arthritic Patients With Osteoporosis
Withdrawn before enrolling
Conditions studied: Osteoporosis, Knee Osteoarthritis
In brief
The purpose of this study is to generate proof of concept human data by evaluating osteoarthritis outcome measures in arthritic patients that are prescribed Forteo® as the standard of care to treat their primary diagnosis of osteoporosis.
Key facts
- Study ID
- NCT03217513
- Run by
- Edward Fox
- People needed
- 0
- Starts
- 2020-01-01
- Expected to finish
- 2024-12-31
- Last updated by the study team
- 2019-10-24
Who can join
Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age: 40-80 years (inclusive)
- Gender: male or female (non-pregnant)
- Fluent in written and spoken English
- Patients capable of giving informed consent
- Primary diagnosis of osteoporosis that will be treated with either Forteo® to induce bone anabolism or Prolia® by the study investigator as part of patient's standard of care treatment
- Symptomatic, medial compartment knee OA with a Kellgren-Lawrence (K-L) score between II-III (documented in the medical record by previously collected knee series radiography). Radiographs to be performed within past two years.
You may not qualify if…
- Age < 40 or >80 years
- Cognitive impairment
- Pregnancy
- Non-English speaking persons
- History of hyperparathyroidism, hypercalcemia, current/recent renal stones, or malignancy
- Depression (currently taking home medication)
- History of inflammatory disease (colitis, rheumatoid arthritis, psoriasis, lupus, scleroderma, spondylitis)
- Use of immunosuppressants, chemotherapy, or radiotherapy
- BMI, angular deformity and K-L score of the contralateral knee (if the OA is bilateral) will be noted as covariates
Where it is running
- Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
Full record on ClinicalTrials.gov
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