ADCC Mediated B-Cell dEpletion and BAFF-R Blockade

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Autoimmune Hepatitis

In brief

VAY736 dose testing; VAY736 efficacy and safety testing.

Key facts

Study ID

NCT03217422

Run by

Novartis Pharmaceuticals

People needed

68

Starts

2018-02-15

Expected to finish

2025-12-17

Last updated by the study team

2026-02-19

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Southern California Research Center — Coronado, California, United States
• Inland Empire Liver Foundation — Rialto, California, United States
• University of California Davis Medical Center — Sacramento, California, United States
• St. Lukes Advanced Liver Therapies — Houston, Texas, United States
• Novartis Investigative Site — CABA, Buenos Aires, Argentina
• Novartis Investigative Site — CABA, Argentina
• Novartis Investigative Site — Ghent, Belgium
• Novartis Investigative Site — Edmonton, Alberta, Canada
• Novartis Investigative Site — Toronto, Ontario, Canada
• Novartis Investigative Site — Montreal, Quebec, Canada
• Novartis Investigative Site — Prague, Czechia
• Novartis Investigative Site — Würzburg, Bavaria, Germany
• Novartis Investigative Site — Aachen, Germany
• Novartis Investigative Site — Hamburg, Germany
• Novartis Investigative Site — Hanover, Germany
• Novartis Investigative Site — Mainz, Germany
• Novartis Investigative Site — Sapporo, Hokkaido, Japan
• Novartis Investigative Site — Takamatsu, Kagawa-ken, Japan
• Novartis Investigative Site — Itabashi Ku, Tokyo, Japan
• Novartis Investigative Site — Barcelona, Spain
• Novartis Investigative Site — Madrid, Spain
• Novartis Investigative Site — Madrid, Spain
• Novartis Investigative Site — Bern, Switzerland
• Novartis Investigative Site — Birmingham, West Midlands, United Kingdom
• Novartis Investigative Site — London, United Kingdom

Full record on ClinicalTrials.gov

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