Effects of Change in Insulin Resistance and Systemic Inflammation on Brain Structure and Function

Completed

Conditions studied: Obesity, Bariatric Surgery Candidate

In brief

Obesity is associated with alterations in brain structure and cognitive impairment and is a risk factor for Alzheimer's disease and vascular dementia. The mechanisms underlying obesity related decline in cognitive function are not fully understood. The long-term goal of this project is to understand how obesity affects cognitive function, with the aim to develop new ways to prevent and treat obesity related cognitive decline

Key facts

Study ID

NCT03215888

Run by

University of Minnesota

People needed

29

Starts

2017-11-01

Expected to finish

2020-02-11

Last updated by the study team

2021-07-02

Who can join

Age: 30 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Obese Group
• Undergoing VSG-type bariatric surgery
• BMI > 30
• Current weight less than 400 lbs
• Non-Obese Group
• Age 30-50
• BMI < 25

You may not qualify if…

• Both Groups
• History of type 1 or type 2 diabetes
• History of stroke
• History of epilepsy
• History of Neurosurgical procedures
• Past or current history of severe psychiatric illness
• Pass or current history of alcohol or substance abuse
• Absence of metallic substances in body or ability to remove before imaging procedure
• History of claustrophobia or known inability to tolerate MRI
• Inability to consent

Where it is running

• Clinical and Translational Science Institute and Center for Magnetic Resonance Research, University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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