Effects of Nasal High-flow Oxygen in Patients With an Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

Completed · Not applicable

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

The investigators are looking at the effect of humidified nasal high-flow with oxygen (HNHF-O2) on air exchange during exacerbations of COPD. HNHF-O2 therapy may have beneficial effects in patients with severe breathing impairment that results in low oxygen in the blood. Some studies show that patients with low blood oxygen levels who use HFNC oxygen have lower rates of needing mechanical ventilation.

Key facts

Study ID: NCT03214458
Run by: Temple University
People needed: 10
Starts: 2017-07-20
Expected to finish: 2018-04-18
Last updated by the study team: 2018-04-19

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Males and females 40 years of age or older
Hospitalized for an acute exacerbation of COPD on the 6th floor of Rock Pavilion (pulmonary inpatient service)
Smoking history of > 10 pack-years
PaCO2 ≥ 45 mm Hg
Able to provide informed consent
Willing to participate in daily measurements of arterial blood gases, completion of study questionnaires, and other study-related procedures

You may not qualify if…

Upper airway or nasal problems that prohibit the use of humidified high-flow nasal oxygen
Hemodynamic instability defined as the need for blood pressure or blood volume support to maintain adequate tissue perfusion and oxygenation
Urgent need for endotracheal intubation
A do-not-intubate order
A known diagnosis of obstructive sleep apnea
Present use of continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BIPAP) therapy

Where it is running

Temple University Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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