A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain

Completed · Phase 3 · Has a placebo group

Conditions studied: Endometriosis

In brief

The objective of this study is to evaluate safety and efficacy of elagolix in the management of moderate to severe endometriosis-associated pain in adult premenopausal female participants including the safety and efficacy of elagolix in combination with concomitant hormonal add-back therapy.

Key facts

Study ID

NCT03213457

Run by

AbbVie

People needed

681

Starts

2017-07-07

Expected to finish

2023-12-06

Last updated by the study team

2024-12-20

Who can join

Age: 18 and older, up to 49. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Participant is a premenopausal female 18 to 49 years of age (inclusive) at the time of Screening.
• Participant has a documented surgical diagnosis (e.g., laparoscopy or laparotomy) of endometriosis established by visualization within 10 years prior to entry into Washout or Screening.
• Participant must agree to use only protocol specified rescue analgesics during the Screening and Treatment Periods for endometriosis-associated pain.
• Participant must have the following documented in the e-Diary during the last 35 days prior to Study Day 1:
• At least 2 days of "moderate" or "severe" dysmenorrhea (DYS) AND either
• At least 2 days of "moderate" or "severe" non-menstrual pelvic pain (NMPP) and an average NMPP score of at least 1.0, OR
• At least 4 days of "moderate" or "severe" NMPP and an average NMPP score of at least 0.5.

You may not qualify if…

• Participant has chronic pelvic pain that is not caused by endometriosis, that requires chronic analgesic therapy, which would interfere with the assessment of endometriosis-related pain.
• Participant is using any systemic corticosteroids for over 14 days within 3 months prior to Screening or is likely to require treatment with systemic corticosteroids during the course of the study. Over-the-counter and prescription topical, inhaled or intranasal corticosteroids are allowed.
• Participant has a history of any major depression or post-traumatic stress disorder (PTSD) within 2 years of the screening visit or other major psychiatric disorder at any time.
• Participant has a history of suicide attempts or answered "yes" to questions 4 or 5 on the suicidal ideation portion of the Columbia-Suicide Severity Rating Scale (C-SSRS) within the last 1 year at Screening or prior to randomization on Day 1.
• Participant has any history of osteoporosis or other metabolic bone disease or any condition that would interfere with obtaining adequate dual energy x-ray absorptiometry (DXA) measurements
• Screening DXA results of the lumbar spine (L1-L4), femoral neck or total hip bone mineral density (BMD) corresponding to less than 2.0 or more standard deviations below normal.
• Participant has either:
• a newly diagnosed, clinically significant medical condition that requires therapeutic intervention (e.g., new onset hypertension), that has not been stabilized 30 days prior to randomization on Day 1 OR
• a clinically significant medical condition that is anticipated to require intervention during the course of study participation (e.g., anticipated major elective surgery) OR
• an unstable medical condition that makes the subject an unsuitable candidate for the study in the opinion of the Investigator, (including, but not limited to, uncontrolled diabetes mellitus, uncontrolled hypertension, epilepsy requiring anti-epileptic medication, unstable angina, confirmed inflammatory bowel disease, hyperprolactinemia, clinically significant infection or injury).
• Participant has any conditions contraindicated with use of E2/NETA.

Where it is running

• Alabama Clinical Therapeutics, LLC /ID# 145503 — Birmingham, Alabama, United States
• Alabama Clinical Therapeutics, LLC /ID# 151468 — Birmingham, Alabama, United States
• Southern Women's Specialists PC /ID# 148750 — Fairhope, Alabama, United States
• Women's Health Alliance of Mobile /ID# 150083 — Mobile, Alabama, United States
• University of South Alabama /ID# 148774 — Mobile, Alabama, United States
• Mobile, Ob-Gyn, P.C. /ID# 145364 — Mobile, Alabama, United States
• Mesa Obstetricians and Gynecologists /ID# 147320 — Mesa, Arizona, United States
• Arizona Research Assoc /ID# 161703 — Tucson, Arizona, United States
• Eclipse Clinical Research /ID# 155600 — Tucson, Arizona, United States
• Unity Health- Searcy Medical Center /ID# 203674 — Searcy, Arkansas, United States
• Core Healthcare Group /ID# 149321 — Cerritos, California, United States
• HRC Fertility /ID# 154143 — Encino, California, United States
• Glendale Adventist Medical Ctr /ID# 160530 — Glendale, California, United States
• HCP Clinical Research LLC /ID# 152045 — Huntington Beach, California, United States
• Alliance Research Centers /ID# 151240 — Irvine, California, United States
• Long Beach Clinical Trial Serv /ID# 152428 — Long Beach, California, United States
• Olympia Clinical Trials /ID# 202325 — Los Angeles, California, United States
• California Medical Research As /ID# 154746 — Northridge, California, United States
• Futura Research, Org /ID# 145406 — Norwalk, California, United States
• Huntington Medical Foundation /ID# 154750 — Pasadena, California, United States
• Northern California Research /ID# 159753 — Sacramento, California, United States
• Precision Research Institute - San Diego /ID# 152557 — San Diego, California, United States
• MD Strategies Research Centers /ID# 152429 — San Diego, California, United States
• Alta California Medical Group /ID# 155706 — Simi Valley, California, United States
• Central Research Associates /ID# 163087 — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.