Children's Respiratory and Environmental Workgroup
Completed
Conditions studied: Asthma, Allergic Asthma, Allergies, Healthy
In brief
The environment during the prenatal period and in early life is a major contributor to the risk of developing childhood asthma. Birth cohort studies from single research centers have identified several factors that affect the risk for developing childhood asthma, including being exposed in early life to allergens, pollutants, viruses and bacteria, and psychosocial stress. Despite such advances, further progress in understanding the root causes of asthma have been hampered by the small size of previous studies, which makes it difficult to: 1) identify asthma risk factors with certainty, 2) know how environmental factors across the United States (U.S.) affect asthma, and 3) whether there are critical ages when pregnant mothers, infants and young children are particularly susceptible to these influences. Furthermore, different research groups tend to use different methods to study asthma, making it difficult to either compare or pool findings. One other challenge is that there are several types (i.e. phenotypes, endotypes) of childhood asthma, but these are poorly understood. To help overcome these challenges, investigators leading 12 asthma birth cohorts across the U.S. have established the Children's Respiratory Research Workgroup (CREW) consortium. CREW proposes to identify specific types of childhood asthma, develop an understanding of what early life environmental influences cause these different types of asthma and when, and identify targets for future efforts aimed at preventing childhood asthma.
Key facts
- Study ID
- NCT03213184
- Run by
- University of Wisconsin, Madison
- People needed
- 142
- Starts
- 2017-12-26
- Expected to finish
- 2023-06-30
- Last updated by the study team
- 2023-08-14
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participant and/or parent guardian must be able to understand and provide informed consent or assent (if required).
- Participation in one of the 10 cohorts that make up CREW.
You may not qualify if…
- Inability or unwillingness of a participant to give informed consent or assent (if required) or comply with study protocol.
- Past or current medical problems or findings from physical examination or laboratory testing which, in the opinion of the investigator or designee, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.
Where it is running
- Johns Hopkins University — Baltimore, Maryland, United States
- Brigham and Women's Hospital — Boston, Massachusetts, United States
- Boston University School of Medicine — Boston, Massachusetts, United States
- Henry Ford Health System — Detroit, Michigan, United States
- Washington University — St Louis, Missouri, United States
- Columbia University Medical Center — New York, New York, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- UW Madison — Madison, Wisconsin, United States
- Marshfield Clinic — Marshfield, Wisconsin, United States
Full record on ClinicalTrials.gov
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