Study Assessing the Efficacy and Safety of Intravitreal Injections of DE-122 in Combination With Lucentis® Compared to Lucentis® Monotherapy in Wet Age-related Macular Degeneration Subjects

Completed · Phase 2 · Has a placebo group

Conditions studied: Age-Related Macular Degeneration

In brief

To assess the safety and efficacy of repeated intravitreal injections of DE-122 (low dose and high dose) given in combination with Lucentis® in subjects with wet age-related macular degeneration (AMD) compared with Lucentis® alone.

Key facts

Study ID

NCT03211234

Run by

Santen Inc.

People needed

76

Starts

2017-07-05

Expected to finish

2020-01-31

Last updated by the study team

2021-07-13

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provide signed written informed consent
• Diagnosis of active choroidal neovascularization secondary to wet AMD
• BCVA of 65 to 25 ETDRS letters (20/50 to 20/320) in the study eye
• BCVA of 25 ETDRS letters (20/320) or better in the fellow eye

You may not qualify if…

• [Ocular]
• Use or anticipated use of any intravitreal, periocular or photodynamic therapy in the study eye for the treatment of AMD within a specified timeframe prior to Visit 1 and throughout the study
• Uncontrolled or advanced glaucoma, chronic hypotony or vitrectomy in the study eye
• Evidence of any other ocular disease other than exudative age-related macular degeneration in the study eye that may confound the outcome of the study
• Need for ocular surgery in the study eye during the course of the study
• Presence or history of certain ocular or periocular pathology or conditions that could limit the ability to perform examinations
• [Non-ocular]
• Allergy or hypersensitivity to study drug product, fluorescein dye or other study related procedures and medications
• Current or history of certain systemic conditions, abnormalities or therapies that would render a subject a poor candidate for the study
• Participation in other investigational drug or device clinical trials within 30 days prior to randomization or planning to participate in other investigational drug or device clinical trials for the duration of the study
• Females who are pregnant or lactating and females of child-bearing potential who are not using adequate contraceptive precautions and men who do not agree to practice an acceptable method of contraception throughout the course of the study
• Unable to comply with study procedures or follow-up visits

Where it is running

• Retina Research Institute — Gilbert, Arizona, United States
• Retina-Vitreous Associates — Beverly Hills, California, United States
• Northern California Retina Vitreous Associates — Mountain View, California, United States
• Bay Area Retina Associates — Walnut Creek, California, United States
• Colorado Retina Associates — Golden, Colorado, United States
• National Ophthalmic Research Institute — Fort Myers, Florida, United States
• Black Hills Regional Eye Institute — Rapid City, South Dakota, United States
• Retina Reseach Center — Austin, Texas, United States
• Retina Consultants of Houston — Houston, Texas, United States
• Valley Retina Insititute — McAllen, Texas, United States
• Asian Eye Institute — Makati City, Philippines
• Peregrine Eye and Laser Institute — Makati City, Philippines
• The Medical City — Pasig, Philippines
• St. Luke's Medical center Quezon City — Quezon City, Philippines

Full record on ClinicalTrials.gov

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