Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Posttraumatic Stress Disorder

In brief

The investigators will test whether intranasal oxytocin (24 IU vs placebo) will induce effects on attention bias and startle comparable to those the investigators have shown to be induced by the presence (vs absence) of a service dog in Veterans diagnosed with PTSD. This possibility is suggested by a 2015 study showing that urinary oxytocin levels are elevated in association with mutual gaze between dogs and their owners.

Key facts

Study ID

NCT03211013

Run by

Palo Alto Veterans Institute for Research

People needed

17

Starts

2017-07-10

Expected to finish

2021-06-09

Last updated by the study team

2021-06-10

Who can join

Age: 18 and older, up to 65. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• US military Veteran
• Current posttraumatic stress disorder
• Medically healthy

You may not qualify if…

• DSM-5 diagnosis of schizophrenia, schizoaffective disorder, or psychotic disorder
• Active drug or alcohol use disorder within past 90 days
• Currently participating in a clinical drug trial
• Regular nasal obstruction or nosebleeds (use of saline or nasal decongestant permitted if subject has transient cold only)
• Active medical problems: unstable seizures, significant physical illness (e.g., serious liver, renal, or cardiac pathology)
• Sensitivity to preservatives, in particular E 216, E 218, and chlorobutanol hemihydrate
• Significant hearing or vision impairments
• Habitually drinks large volumes of water

Where it is running

• VA Palo Alto Health Care System — Menlo Park, California, United States

Full record on ClinicalTrials.gov

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