Global Electrical Heterogeneity and Clinical Outcomes

Completed

Conditions studied: Heart Failure, Implantable Defibrillator User, Ventricular Arrythmia

In brief

This retrospective multicenter cohort will validate an independent association of electrocardiographic (ECG) global electrical heterogeneity (GEH) measures with sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD, and will validate and re-calibrate GEH ECG risk score for prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD.

Key facts

Study ID

NCT03210883

Run by

Larisa Tereshchenko

People needed

3471

Starts

2017-07-01

Expected to finish

2021-07-05

Last updated by the study team

2021-07-08

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• records of systolic heart failure patients with primary prevention ICDs/CRT-Ds implanted for routine clinical indications

You may not qualify if…

• absent baseline pre-implant digital ECG;
• missing data on clinical predictors and covariates;
• missing ICD programming data (including number of intervals to detect [NID] or time to detect, number of detection zones, heart rate for each detection zone, and anti-tachycardia pacing [ATP] programming);
• missing outcomes data.
• records of patients with inherited channelopathies (e.g. long QT syndrome, Brugada syndrome), inherited cardiomyopathies (e.g. hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy), and congenital heart disease.

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Stanford University — Stanford, California, United States
• University of Colorado — Aurora, Colorado, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Oregon Health and Science University — Portland, Oregon, United States
• Veteran Administration Portland Healthcare System — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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