The Impact of Contact Lens Coefficient of Friction (CoF) on the Development of Lid Wiper Epitheliopathy (LWE)

Completed · Phase 4

Conditions studied: Lid Wiper Epitheliopathy

In brief

This study examines the development of Lid Wiper Epitheliopathy (LWE) in individuals fit with contact lenses having difference coefficients of friction (CoF)

Key facts

Study ID

NCT03209505

Run by

University of Houston

People needed

20

Starts

2017-06-26

Expected to finish

2018-04-13

Last updated by the study team

2021-08-31

Who can join

Age: 18 and older, up to 46. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must be able to read and understand the study informed consent
• Must be a minimum of 18 years of age and less than 46 years of age at study enrollment
• Must be healthy non-soft contact lens wearers (neophytes), or experienced contact lens wearers that have not worn their contact lenses for a minimum of 7 days
• Have a spherical equivalent refractive error between -0.75 to -6.50DS at the spectacle plane
• The subject must be able to attend study visits at the prescribed visit times and adhere to the study instructions

You may not qualify if…

• Pregnant and/or lactating females by self-report
• Presence of current LWE on the upper eyelid (>0.5 in height or width)
• Has greater than -1.00DC of refractive cylinder
• Has greater than 1.00D of anisometropia
• Is aphakic
• Has clinically significant corneal or conjunctival staining that would prevent contact lens fitting, as assessed with sodium fluorescein dye
• Has significant ocular surface disease (e.g. Sjögrens Disease, Stevens-Johnson Syndrome, etc.) or significant Dry Eye Syndrome
• Has clinically significant corneal vascularization or central corneal scaring
• Has active ocular surface infection (e.g. conjunctivitis)
• Has a positive history of eyelid surgery or trauma
• Has a positive history of refractive surgery
• Takes medications that significantly impact contact lens comfort and/or ocular surface health
• Has taken part in another contact lens or contact lens solution clinical trial within the last 7 days
• Is unwilling to have eyes photographed or video recorded

Where it is running

• The Ocular Surface Institute, The University of Houston College of Optometry — Houston, Texas, United States

Full record on ClinicalTrials.gov

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