The Brain Ketone Body Challenge Imaging Study

Withdrawn before enrolling · Not applicable

Conditions studied: Alzheimer Disease

In brief

The Brain Ketone Body Challenge Imaging Study will measure how the brain uses different fuels. To do this, radioactive compounds will be used during Positron Emission Tomography (PET) imaging. These compounds, called \[11C\]Acetoacetate (AcAc) and \[18F\] Fludeoxyglucose (FDG), are similar to the sugars and fats the brain already uses for fuel. These compounds safely allow researchers to see how the brain uses sugars and fats during PET scans.

Key facts

Study ID

NCT03204604

Run by

Wake Forest University Health Sciences

People needed

0

Starts

2016-08-08

Expected to finish

2019-03-01

Last updated by the study team

2019-03-19

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Mild Cognitive Impairment (MCI)
• Stable medical condition
• Stable on medications for past 4 weeks
• Women must be post-menopausal

You may not qualify if…

• Diagnosis of neurodegenerative illness (except for MCI)
• History of a clinically significant stroke
• Current evidence or history in past year of focal brain lesion, head injury with loss of consciousness or meeting any Diagnostic and Statistical Manual 4 (DSM-IV) criteria for major psychiatric disorder including psychosis, major depression, bipolar disorder, alcohol or substance abuse
• Diabetes that requires current use of diabetes medications
• Current use of cholesterol/lipid lowering medications
• History of epilepsy or seizure within past year
• Contraindications for imaging (e.g. claustrophobia or high prior radiation exposure)

Where it is running

• Wake Forest School of Medicine — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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