Metabolic Health in Individuals With Spinal Cord Injury (SCI)

Completed · Not applicable

Conditions studied: Spinal Cord Injuries, Skeletal Muscle Atrophy, Metabolic Disease

In brief

Individuals with spinal cord injury (SCI) live longer than before and live to an age where metabolic disorders become highly prevalent. Due to loss of mobility and severe skeletal muscle atrophy, obesity, glucose intolerance, and peripheral insulin resistance develop soon after the onset of SCI. These abnormalities are thought to contribute to the increased diabetes disease risk and accelerated aging process in the SCI population. As a result of these trends, overall burden of complications, economic impact and reduced quality of life are increasing. Until there are effective treatments for SCI, it is imperative to develop effective interventions to mitigate metabolic disorders that develop in individuals with SCI. The proposed research project examines the impact of early utilization of a novel neuromuscular electrical stimulation (NMES) program on skeletal muscle metabolism and overall metabolic health in individuals with sub-acute, complete SCI.

Key facts

Study ID

NCT03204240

Run by

Ohio State University

People needed

40

Starts

2018-01-01

Expected to finish

2022-08-31

Last updated by the study team

2023-03-27

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• between the ages of 18 and 60 years;
• diagnosis of traumatic SCI at the cervical or thoracic level (C5-T12) classified as AIS A (motor and sensory complete);
• within 14 days of the SCI and the first week of initial inpatient rehabilitation;
• medically stable at the time of testing;
• no history of metabolic syndrome and/or type 1 or type 2 diabetes.

You may not qualify if…

• Pregnant women
• Orthopedic condition that limits lower extremity function
• Neurological (other than SCI), vascular, or cardiac problems that may limit function and interfere with testing procedures
• Have 1 or more contraindications to NMES
• Have lidocaine or iodine allergy

Where it is running

• UAB — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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