The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection

Status unconfirmed

Conditions studied: Prosthetic Joint Infection

In brief

This is a prospective multicenter study. All patients presenting for revision hip or knee arthroplasty for all indications under the respective surgeon's care may be eligible. Per standard of care preoperatively, all patients must have blood drawn for erythrocyte sedimentation rate(ESR), C-reactive protein(CRP) and D-dimer. Aspiration of the joint in question may be performed at the discretion of the treating surgeon and results documented. Intraoperative samples will also be collected and sent for NGS analysis

Key facts

Study ID

NCT03200470

Run by

Rothman Institute Orthopaedics

People needed

120

Starts

2017-02-16

Expected to finish

2018-03-01

Last updated by the study team

2017-10-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing primary total hip or knee arthroplasty with no history of prior surgery
• Patients undergoing revision hip or knee arthroplasty for septic or aseptic indication.

You may not qualify if…

• Patients undergoing second stage re-implantation surgery for PJI.

Where it is running

• Rothman Institute — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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